Well we've got a whole assortment of players out or questionable for both teams heading into Sunday's matchup.  The biggest name would have to be Steven Jackson, the Rams running back.  We'll get a chance to see a whole lot of Antonio Pittman and maybe throwback Travis Minor.

49ers
Probable: RB Frank Gore (neck)

Questionable: FS Mark Roman (groin)

Doubtful: OT Barry Sims (ankle), TE Delanie Walker (shoulder)

Out: WR Arnaz Battle (foot), S Dashon Goldson (knee), WR Josh Morgan (groin)

Rams
Probable: WR Derek Stanley (ankle), DT Adam Carriker (ankle), QB Trent Green (elbow), RB Antonio Pittman (hamstring)

Questionable: OT John Greco (knee)

Out: RB Steven Jackson (thigh), LB Chris Draft (foot), CB Tye Hill (knee), DE Eric Moore (spine)

Pittman was a full participant in practice all week so I'd imagine the listing of probable probably doesn't mean a whole lot.  Of course hamstrings can be tricky so he'll be a guy to keep an eye on.  I'd imagine as bad as things have been for the Rams, they really don't want to have to rely on Travis Minor.

I'm very curious to see how the 49ers handle the free safety position if Roman can't play.  Goldson is the backup free safety, so with him being out, Keith Lewis could see a whole lot of playing time.  I believe rookie DB Reggie Smith can play a little bit of safety, but I'd expect Keith Lewis to get more playing time first.  Considering Roman's struggles, it might be nice to see some of the young guys get some more playing time, even if it's a guy like Reggie Smith ending up slightly out of position.  We want to know what these guys bring to the table, so might as well throw them in the deep end.