We've got the final injury report for the week, but there remain a lot of question marks. The Colts have listed Dwight Freeney and Reggie Wayne as Questionable, which means there's a 50-50 chance they'll play. I'd imagine most folks are anticipating they'll play, because the "Questionable" designation is more or less a joke in the NFL. Both Freeney and Wayne were full participants in practice today. Had they missed practice again I'd be wondering, but at this point I'd be stunned if they didn't play.
As for the 49ers, Mike Singletary has indicated Takeo Spikes will be a game-time decision. Given how much time the team will likely spend in the nickel defense, and given that Takeo Spikes usually comes out of the game in those situations, one has to wonder if he'll be active on Sunday.
S Reggie Smith (groin)
DE Ray McDonald (ankle)
LB Takeo Spikes (shoulder)
RB Donald Brown (shoulder)