49ers vs. Bills: Isaac Sopoaga looking unlikely to play

The 49ers will release their inactives at approximately 12:55pm PT, but we are starting to get some ideas about who might be inactive today.

Isaac Sopoaga sat out last week's game with ankle and knee issues that kept him out of practice. Ice returned to practice this week in a limited fashion, and it seems like the 49ers are content to wait another week to get him back in the starting lineup.

If Sopoaga is inactive, Ricky Jean Francois will start in his place. Will Tukuafu is currently listed as the primary backup to Sopoaga, but RJF is the guy who has started in Ice's place during injuries. Ian Williams is listed behind Tukuafu, but would likely be the primary backup to RJF for today's game.

The inactives will come out in less than half an hour, at which point we'll get official news on Sopoaga, as well as the two other "questionable" players: Carlos Rogers and Brandon Jacobs. Both are expected to play, but we'll wait for final word.

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