49ers vs. Giants odds: SF opens as sizable favorite yet again

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We take a look at the 49ers odds against the Giants early in Week 6.

The 49ers host the New York Giants this Sunday in a game with some modest early season playoff implications. The 49ers will enter the game as a favorite for the fifth straight week, and currently sit as a six to seven point favorite in the game. If the line holds at seven or more, this will mark the fourth game they will have a touchdown or more spread. They were 4.5 point favorites over the Jets and six point dogs to the Packers.

The 49ers are currently 4-1 against the spread, with their loss to Minnesota sitting as their only loss against the spread. It is too early to make anything of the numbers, but I do think this is a spread the 49ers can cover. The Giants have been all over the place, but the 49ers have looking quite strong at home. If they can take an early lead on the Giants like the Browns did, I have to think they are more likely to hang on to that lead.

Looking through the rest of the 49ers schedule, they are likely to be favored in eight, and possibly nine of those games. The 49ers could be a road dog against the Seahawks or Cardinals, but if they keep up their current pace, I think they will be favored in those games. That leaves road games against the Saints and Patriots where they could be underdogs. I am fairly certain the 49ers will be slim underdogs at New England. The Saints game will depend on if the Saints build some momentum off their comeback win over the Chargers.

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