Answer: Sort of, maybe
1. Keep him in the pocket.
As he is the shiftiest QB we've seen a long time, this is easier said than done. However, with an elite defensive line that maintains their discipline, it is possible to keep him in the pocket much of the time. In the pocket his height is indeed a disadvantage, since his throwing lanes are narrower than other QB's. Minimizing his escapes cuts down on Seattle's big play opportunities.
2. Play his roll outs correctly.
Wilson will escape the pocket sometimes, despite all efforts to the contrary. Two weeks ago, the 49ers played these occasions as well as possible. (A.) One defensive player must prevent Wilson from running by turning into a spy. This player must be, again, very disciplined, and take a conservative approach, not going for a deep sack but guarding the angles. (B.) Another/other player(s) have to coordinate to guard reveivers coming back to the near side and near middle. All of the big plays Wilson has achieved on his roll outs, have, to my recollection of the 3-4 Seahawks games I've seen, been to the near sideline and the near middle. If A. and B. are done poorly, we see outcomes like in the Texans 4th quarter collapse against the Seahawks. If both of them are done well, we see games where Seattle's offense struggles to pick up chunks (against 49ers and Cardinals).
Of course, for this to be effective in the context of an entire gameplan, a Defense has to also limit Marshawn Lynch on the ground, which great defenses have been able to do this year. Seattle will still score points. Their receiving core is not elite, but have good chemistry with Wilson, and know how get open on broken plays.
In Summary, It appears as though a disciplined, precise game by a great defense can keep Seattle to somewhere between 13-17 points. That team's offense then has the onus. One thing that occurs is how much the Seahawks are missing having a healthy Percy Harvin. Not only would he bring a speed and talent upgrade to the WR core, but his incorporation would likely involve offensive plays that we have not seen much of, and may not be as well prepared for...
On a different note, i do think, as has been mentioned, that WR's being the aggressors is part of the achilles heal of Seattle's secondary, and combating what they get away with. Maybe someone less lazy than I will put together a post synthesizing different ways to attack a lanky, aggressive, press-coverage secondary. If Lester the Molester is Richard Sherman's inspiration, how did offenses have success against those early 1980's raiders secondaries? What teams have had the most success passing on Seattle's defense and how?
Thanks for reading my first fanpost, Thoughts?