Conversely, the Panthers won't be having an easy time. They'll be on the road, they will be six weeks past their bye and they'll be in the middle of their toughest stretch of games all season. Before facing the Niners, they'll play the Falcons. After playing the Niners, they'll play the Patriots.
While the Panthers certainly produced on offense last year (12th overall in yards per game), their defense let them down and they ultimately wound up with 22.7 points allowed per game while earning 22.2 on offense. The team attempted to remedy this in the draft, using 3/5 of their picks on tackles star Star Lotulelei and Kawann Short and Linebacker AJ Klein. They also picked up ex-49er Ted Ginn, Jr. -- on their roster he's listed as a wide receiver, but he's known for his special teams play as a returner.
Here are some stats from the Panthers' last season:
Passing: 230.2 yds/game, 7.5 yds/att
Passing leader: Cam Newton 3,869 yds
Receiving leader: Steve Smith, 1,174 yds
Rushing: 130.5 yds/game, 4.5 yds/att
Rushing leader: Cam Newton, 741 yds
Passing allowed: 223 yds/game, 6.4 yds/att
Rushing allowed: 110.1 yds/game, 4.2 yds/att
Points allowed: 22.7/game