Can Fred Jackson or C.J. Spiller delivery a solid fantasy performance against the stout San Francisco 49er defense in Week 5? Will Ryan Fitzpatrick have another 3 quarters of excellent play and meltdown in the fourth? Will Frank Gore continue to make

With Brandon Jacobs returning to action, the San Francisco 49ers may have to deactivate another regular contributor. We discuss the situation at the Niners Nation.

We break down the news surrounding the injuries to Bills offensive linemen Cordy Glenn and Kraig Urbik.

We take a look at where the 49ers-Bills game will be broadcast in the US, Canada, UK and Germany, according to the506.com and other sites.

We break down the 49ers and Bills injury reports for Wednesday

We look at the heachaches Colin Kaepernick is creating for the Bills coaching staff, even if he does not play.

We break down the public transportation options in San Francisco for Sunday's 49ers-Bills game, on a busy day in the Bay Area

We breakdown the mismatch of the week when the San Francisco 49ers and Buffalo Bills face off at Candlestick Park.

We take a look at the announcer crew for the Week 5 matchup between the 49ers and Bills.

We take a look at pertinent facts, figures and history in the 49ers Week 5 matchup with the Buffalo Bills