A 49ers-Seahawks Week 16 preview, featuring five questions with SB Nation's Seahawks blogger.

With San Francisco 49ers defensive lineman Justin Smith possibly sidelined for Sunday's game, we breakdown how Ahmad Brooks and Ray McDonald can pick up the slack.

We take a look at Jim Harbaugh's press conference transcript for Friday heading into Sunday's 49ers-Seahawks Week 16 matchup.

Debating on starting a 49er or Seahawk in the fantasy football championship? I'm sorry, but here is a breakdown of the key players in this match-up.

The San Francisco 49ers will have their sixth primetime match-up of the season in Week 16. In five previous games this season, the Niners have gone a perfect 5-0.

We break down the news that Cam Johnson will be promoted from practice squad to 53-man roster. We also look at the updated injury report for Sunday.

We take a look at the latest news surrounding Seahawks cornerback Richard Sherman and his appeal of a PED suspension. He is expected to play on Sunday.

We take a look at Vic Fangio's press conference transcript in advance of 49ers-Seahawks