The list today includes two of the best defensive backs and one of the best safeties to ever play for the 49ers, as well as one of the best RBs to play for the 49ers. Lots of talent today.
| Player | Position | College | Spot Drafted | Years Played | Jersey Number |
| Randy Baldwin | RB | Mississippi | 92nd | 1995 | 21 |
| Frank Gore | RB | Miami (Fla.) | 65th | 2005-- | 21 |
| Larry Jones | WR | NE MIssouri State | 367th | 1978 | 21 |
| RW McQuarters | CB | Oklahoma State | 28th | 1998-99 | 21 |
| Anthony Parker | CB | Weber STate | 99th | 1999-2002 | 21 |
| Deion Sanders | DB | Florida State | 5th | 1994 | 21 |
| Eric Wright | CB | Missouri | 40th | 1981-1990 | 21 |
| Tony Blevins | SW | Kansas | Undrafted | 1998 | 22 |
| Todd Bowles | S | Temple | Undrafted | 1991 | 22 |
| Ray Brown | RB | South Carolina | 259th | 1987 | 22 |
| Nate Clements | CB | Ohio State | 21st | 2007-- | 22 |
| Bob Hayes | WR | Florida A&M | 88th | 1975 | 22 |
| Dwight Hicks | S | Michigan | 150th | 1979-1985 | 22 |
| Terry Jackson | RB | Florida | 157th | 1999-2005 | 22 |
| Amp Lee | RB | Florida State | 45th | 1992-1993 | 22 |
| Eddie Lewis | DB | Kansas | 57th | 1976-1979 | 22 |
| Gary Lewis | FB | Arizona State | 71st | 1964-1969 | 22 |
| Tim McKyer | CB | Texas-Arlington | 64th | 1986-1989 | 22 |
| BJ Tucker | CB | Wisconsin | 178th | 2005-2007 | 22 |
| Vic Washington | RB | Wyoming | 87th | 1971-1973 | 22 |
| Joel Williams | Center | Texas | 198th | 1948 | 22 |
| Tony Cherry | RB | Oregon State | 240th | 1986-1987 | 23 |
| Marcus Hudson | S | North Carolina State | 192nd | 2006-2009 | 23 |
| Ray Norton | HB | San Jose State | 46th | 1960-1961 | 23 |
| George Smith | Center | California | Undrafted | 1947 | 23 |
| Wayne Swinford | DB | Georgia | 114th | 1965-1967 | 23 |
| Bruce Threadgill | S | Mississippi State | 133rd | 1978 | 23 |
| Spencer TIllman | HB | Oklahoma | 133rd | 1989-1991 | 23 |
| Herb Williams | CB | Southern | 139th | 1980 | 23 |
| Jimmy Williams | CB | Vanderbilt | 196th | 2001-2004 | 23 |
| Gerry Conlee | Center | St. Mary's | Undrafted | 1946-1947 | 22 |
The Winners:
Representing the Number 21: Frank Gore. Sanders is one of the best to ever play the position but he only played one year in San Francisco, making this an easy choice for me.
Representing the Number 21: Dwight Hicks. This was a tough one. Eric Wright is deserving of mention as is Nate Clements, but Hicks had a better career than Wright (who was hampered by injuries). Hicks was also part of the 1984 secondary that would be voted en masse to the Pro Bowl, something that's never happened before, or since.
Representing the Number 22: Nate Clements. Dude is a stud and will prove his doubters wrong this season
Representing the Number 23: By unanimous consent I've changed it to Spencer Tillman
Edit: I've made a tie for number 21 because I can't in good conscience leave Dwight Hicks off this list. Nor can I leave Gore off.