NFL picks against the spread, Week 6: 49ers sitting at -11 against the Cardinals

If you are following my picks suggestions week after week, and you dare use them as suggested results for the coming week, any money you may or may not lose is a deserved loss. I continue to struggle under the .500 mark, putting up a 7-9 record for Week 5. We'll see how this week pans out. James (Raiders writer from Cover32.com) had another slightly solid week, with a 9-7 record against the spread.

The most interesting line has to be the Broncos at -27. The line seems exorbitant, but can you really bet against the Broncos at this point? Don't you stick with them as long as they're dominating? And even if they rest Peyton Manning in the fourth quarter, I have to think they could easily win by four touchdowns. What do you think on that line?

The 49ers are 11 point favorites against a tough Arizona Cardinals team. If I was a more objective NFC West observer, I'd probably take the Cardinals to cover and lose. However, I do think the 49ers can cover in this game. The Cardinals offense is talented but incredibly inconsistent. And with Arizona's offensive line woes, the 49ers have a chance to really dominate down front in both the run and pass game.

If the 49ers can shut down Rashard Mendenhall and Andre Ellington, it opens the door for them to potentially tee off on Carson Palmer. He's got great weapons to throw to, but with his lack of mobility, and the Cardinals questionable offensive line, the 49ers have a chance to throw a serious monkey wrench in the works.

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