Iupati left the game in the third quarter after Frank Gore was tackled into the back of his leg. Iupati was seen wearing a knee brace after the game. He has been dealing with a knee injury, and this appeared to aggravate it. Adam Snyder replaced Iupati at left guard. Last week, Iupati seemed to suffer an injury to the same knee, but he was back on the field without missing a snap.
Brown suffered a rib injury in the second quarter while stopping Pierre Thomas near the goal line. He took a shot from someone's knee as the play wrapped up. He was slow getting up and was eventually carted off. Tramaine Brock replaced him in the starting lineup, and Eric Wright moved up into the nickel back role.
Those were the only two notable injuries the 49ers suffered. At one point Donte Whitner was seen on the sideline looking like he was trying to stretch something out, but nothing came of that. The 49ers lost two notable players, but otherwise came through the game relatively unscathed. Reports out of the locker room indicate Eric Reid came away feeling fine. He has been free of concussion symptoms all week, so after today's physical game, hopefully it remains that way.
The team's next game is Monday Night Football against Washington. The 49ers first practice participation report is not due until Thursday, instead of the normal Wednesday. The 49ers have an extra day to get healthy, so we'll see how Brown and Iupati respond to treatment between now and then. Jim Harbaugh is meeting with the media Monday at noon, but I would not expect a significant update at this point.