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Must Start
Russell Wilson: He's a QB1 most weeks, but maybe take off a few points given the match-up and expected poor weather. The Niner defense is a concern, but there are only a handful of quarterbacks I'd play over him this week.
Marshawn Lynch: Frank Gore and Marshawn Lynch have been two of the most dependable fantasy backs for the better part of the last 5-6 years. Gore has slipped some, but Lynch still looks like he could do this another 2-3 years. The most important difference is that Marshawn gets fed and he should find some openings against San Francisco. He has the best shot to score in this game and multiple TDs wouldn't surprise me.
Avoid (Keep in mind I'm a 49er fan)
Colin Kaepernick: He's simply too risky to start one game away from the championship and that is putting it nicely. At best he plays well on your bench and maybe you can use him against San Diego next week. I'd rather start Alex Smith or Andy Dalton. It's officially another botched season for those who drafted him as a starter.
Frank Gore: It's sad to even think it, but there is a real chance Gore's days of being fantasy relevant are over. The Seattle defense is back to their old form and they have been able to contain Frank in recent meetings. I wouldn't start the vet as anything more than a FLEX this week.
Anquan Boldin: Between Kaepernick's shaky play and the stiff opposing defense I'm looking at other options this week. A few names of note: Harry Douglas, Nate Washington and Malcolm Floyd are all guys I'd start over "Q".
Michael Crabtree: He certainly racked up the receptions last week, but not enough yards to get excited about a rebirth. You'd be pretty desperate to start him against Seattle on the road. If you are digging for a WR, look for Marquess Wilson or Rueben Randle, both have plus match-ups.
Vernon Davis: He made some noise about wanting a larger role in the offense, but at this rate that can be done with a 3 catch game. His fantasy season was done 14 weeks ago.
Good luck to those in the playoffs. Hopefully, you'll have a reason to read next week's article for the Saturday game.