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Anquan Boldin, Carlos Hyde to sit out 49ers Friday practice

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We break down the latest news surrounding Anquan Boldin and Carlos Hyde injuries. They both are expected to play, but could be game-time decisions.

The San Francisco 49ers have a couple notable injuries that remain problematic. Jim Tomsula spoke to the media Friday morning and said Anquan Boldin and Carlos Hyde would both be held out from practice, and get their work in on the side.

Boldin is dealing with a tight hamstring that flared up on Thursday. He was questionable last week due to the hamstring, but ended up playing. He was not listed on the Wednesday injury report, but then was added as "limited" on Thursday due to the tightening. Odds seem pretty good he will be listed as questionable once again.

The 49ers head into this weekend with Jerome Simpson on the 53-man roster for the first time. He was activated off the suspended list, and while he could not practice with the team prior to last week, he was able to take part in meetings. He should know the playbook and be a viable option. The bigger question will be working on his timing with Colin Kaepernick. If Boldin is unable to play, Quinton Patton would likely get the start opposite Torrey Smith, but Simpson could have a sizable role off the bench.

Hyde sat out Wednesday and Thursday practices, so sitting out Friday as well is not ideal. It is still possible he will be listed as limited today, but even still, we know he is far from 100 percent. There is some discussion of Hyde's stress fracture injury as a pain management type of thing, but this is not exactly an ideal situation.

Reggie Bush will be active, and then Mike Davis and/or Jarryd Hayne behind him. If Hyde can't play, I could see a rotation between the three of them. If Hyde is active (as I expect), I could see Hayne inactive again, with Bush and Davis rotating behind Hyde.