The San Francisco 49ers return home this week to face the Arizona Cardinals, and it will be yet another uphill slog. The 49ers opened as 9.5-point underdogs, but the line has climbed to ten at some sportsbooks, and even 11.5 at other sportsbooks monitored by OddsShark.
The 49ers are coming off a tough 29-13 road loss to the Seattle Seahawks. The 49ers showed some signs of life in the second and third quarters, but they seemed to take the foot off the pedal a little too frequently. On the other hand, the Arizona Cardinals held off the Cincinnati Bengals on Sunday Night Football. Cincinnati took a lead into the half before Arizona put up 21 points in the third quarter. The bengals rolled back late, but came up short.
This marks the first time the 49ers have been a double digit home underdog since 2006. They were a ten point home underdog to the San Diego Chargers, in a game they lost 48-19. Between 2004 and 2006, the 49ers were double digit home dogs six times. They were 2-4 ATS and 1-5 SU, with the one win being an upset of the Tampa Bay Buccaneers in 2005.
This is also the first time the 49ers have been a home underdog to Arizona since 2009. The 49ers won that one outright, 20-16. The 49ers have been an underdog to Arizona 11 times over the last 11 years, but only once during the Jim Harbaugh era. They were a field goal underdog in Arizona in 2013, but won outright, 23-20.