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49ers vs. Bills: Game time, TV schedule, online streaming, odds, more

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The San Francisco 49ers travel easy in Week 6 to face the Buffalo Bills on Sunday at 10:00 a.m. PT. Find information here on the 49ers-Bills game time, TV channel, live online streaming options, radio, announcers and more!

Welcome back for another week of football! The San Francisco 49ers are back in action after a ten-day layoff and face the Buffalo Bills in Orchard Park. The game kicks off at 10:00 am PT on FOX with Dick Stockton, David Diehl, and Kristina Pink on the call. It’s a primarily regional broadcast, which I broke down here.

The 49ers enter the game at 1-4 and in the midst of a four-game losing streak. Chip Kelly decided on a major change this week, switching from Blaine Gabbert at quarterback to Colin Kaepernick. This marks Kaepernick’s first start since Week 8 of last season. Kaepernick later underwent surgeries on his shoulder, thumb, and knee. The surgeries cost him time in the offseason, which was a big reason he lost the offseason QB competition to Gabbert. While the 49ers got a win in Week 1, things went south in a hurry as the offense could not find consistency. And so, a change has been made, with Kelly looking for some kind of spark.

The 49ers head into the game with Jimmie Ward out this week due to his quadricep injury. He is likely going to miss next week as well, with the bye week hopefully able to get him enough time to full recover. The rest of the injury report includes Ahmad Brooks, DeForest Buckner, Glenn Dorsey, and Jaquiski Tartt listed as questionable. The team will announce their inactives at 8:30 a.m.

The Bills are on a roll heading into this game. They opened the season with two straight losses, but have since won three straight. They won a home game over the Arizona Cardinals 33-18, and then went into New England and Los Angeles for 16-0 and 30-19 wins, respectively. The defense and LeSean McCoy have been the two keys for the Bills leading up to this game.

The 49ers opened as 7.5-point underdogs, but the line has since climbed. It has gone as high as ten points, but most sportsbooks have it around nine points for the time being. I picked the Bills in my SuperContest picks, but I also did that in my part because I want that useless reverse jinx! I could see this game going one of two ways. Colin Kaepernick flashes, particularly on the ground, Carlos Hyde has a huge game, the defense plays well, and the 49ers spring an upset with a 10- or 14-point win. The other side is Kaepernick struggles to do much of anything, he gets sacked two or three times, LeSean McCoy shreds the defense, and they lose by two or three touchdowns (or more). Sure, there are other possibilities, but these seem like the two most likely options for the time being.

Nuts and bolts

Location: New Era Field, Orchard Park, NY
Game time: Sunday, October 16, 10:00 a.m. PT
TV channel: FOX
Online streaming: NFL Game Pass
Radio: 810-AM, 107.7 (Ted Robinson, Tim Ryan) | Full listings
Spanish Radio: KTRB 860-AM (Jesus Zarate, Luis Landero/Gabriel Sotelo)
Matchup history: 6-5
Announcers: Dick Stockton, David Diehl, Kristina Pink (sideline reporter)
Enemy blog: Buffalo Rumblings
Twitter: @ninersnation
Facebook: Go ahead and give us a like!

49ers regular season schedule

Week 1: vs. Los Angeles Rams - 28-0 WIN
Week 2: @ Carolina Panthers - 46-27 LOSS
Week 3: @ Seattle Seahawks - 37-18 LOSS
Week 4: vs. Dallas Cowboys - 24-17 LOSS
Week 5: vs. Arizona Cardinals - 33-21 LOSS
Week 6: @ Buffalo Bills, 10:00 a.m., FOX, Sunday, October 16
Week 7: vs. Tampa Bay Buccaneers, 1:05 p.m., FOX, Sunday, October 23
Week 8: BYE
Week 9: vs. New Orleans Saints, 1:05 p.m., FOX, Sunday, November 6
Week 10: @ Arizona Cardinals, 1:25 p.m., FOX, Sunday, November 13
Week 11: vs. New England Patriots, 1:25 p.m., CBS Sunday, November 20
Week 12: @ Miami Dolphins, 10:00 a.m., FOX, Sunday, November 27
Week 13: @ Chicago Bears, 10:00 a.m., FOX Sunday, December 4
Week 14: vs. New York Jets, 1:05 p.m., CBS Sunday, December 11
Week 15: @ Atlanta Falcons, 1:05 p.m., FOX, Sunday, December 18
Week 16: @ Los Angeles Rams, 1:25 p.m., FOX Saturday, December 24
Week 17: vs. Seattle Seahawks, 1:25 p.m., FOX, Sunday, January 1