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49ers-Cardinals picks and predictions: Can Kyle Shanahan get win No. 1?

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The San Francisco 49ers head on the road for their second road game of the season, facing the Arizona Cardinals in Week 4. We run down various picks and predictions for the game.

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New England Patriots v Arizona Cardinals Photo by Christian Petersen/Getty Images

And just like that, we are a game into Week 4 of the 2017 NFL season. The Green Bay Packers took care of business Thursday evening, beating the Chicago Bears. The Packers have been a bit inconsistent, but they handled things well against their division rival to improve to 3-1, and 1-0 in the division.

Once again, it is time to move on to preparations for the San Francisco 49ers Week 4 matchup with the Arizona Cardinals. This matchup is a chance to highlight the awfulness of the NFC West. The Los Angeles Rams sit atop the division at 2-1, the Cardinals and Seattle Seahawks are 1-2, and the 49ers are bringing up the rear at 0-3.

The 49ers are a touchdown underdog heading into this one. The 49ers are coming off a close 41-39 loss to the Rams, while the Cardinals blew an early lead in losing to the Dallas Cowboys. The 49ers are coming in on three extra days of rest, having played on Thursday Night Football. On the other hand, the Cardinals played on Monday Night Football, which means they are coming in with one less day of rest.

TNF teams facing MNF teams are 7-2 against the spread over the past three years. It’s a small sample size, but it makes sense that a team with extra rest under their belt facing a team on short rest would have a slight edge. The media is not quite as down with that, although we do have some upsets picked. Even Mike Florio thinks the 49ers spring the upset!

What do you think it will take for the 49ers to cover the spread and potentially win outright?

SB Nation: 1 out of 9 pick 49ers
ESPN: 2 out of 10 pick 49ers
CBS Sports: 0 out of 8 pick 49ers
USA Today: 0 out of 5 pick 49ers
Elliott Harrison, NFL.com: Cardinals 31, 49ers 24
Greg Cote, Miami Herald: Cardinals 20, 49ers 17
Dennis Manoloff, The Plain Dealer: Cardinals 24, 49ers 16
Vinnie Iyer, Sporting News: Cardinals 26, 49ers 20
Pro Football Talk: MDS Cardinals 27-21, Florio 49ers 27-23