NFL Week 10 Odds: 49ers are 9.5-point underdogs against Saints

For the fifth consecutive week, the San Francisco 49ers are underdogs. The Niners will take on the New Orleans Saints at the Mercedes-Benz Superdome, with the home team listed as a 9.5 favorite.

This is the biggest spread San Francisco has faced since being 10.5-point underdogs in the 2018 season finale against the Los Angeles Rams. The 49ers have failed to cover in their back-to-back losses against the Seattle Seahawks and Green Bay Packers.

New Orleans is going to be a tough matchup for San Francisco. Drew Brees and the Saints have reeled off five wins in a row and sit on top of the NFC standings.

The 49ers are 4-5 ATS this season, while New Orleans is 3-5. The over/under for this game is set at 49.5, so oddsmakers believe the Saints will win 30-20.

New Orleans looked dominant in their 38-3 trouncing of the Tampa Bay Buccaneers, and if the Niners don’t get some reinforcements back, this one could get ugly. Trent Williams and Brandon Aiyuk are expected to play, while Deebo Samuel, Kendrick Bourne, and Raheem Mostert could also return.

This looks like it will be a kitchen sink game for San Francisco head coach Kyle Shanahan. The 49ers are 4-5, but Shanahan still believes his team could capture one of the NFC’s available playoff spots.

I think the Niners will use every trick in the book to keep this game close for long enough that they cover the 9.5 spread.