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49ers vs. Cardinals: How to watch, stream, game time, and betting odds

The majority of the country will see the Giants and Cowboys today

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San Francisco 49ers v Arizona Cardinals Photo by Norm Hall/Getty Images

It’s earlier than expected, but Trey Lance will make his debut today against the Arizona Cardinals. He won’t have one of the 49ers’ best players in George Kittle. That puts pressure on other players to step it up. Looking at you, Brandon Aiyuk.

If today brings anything, it’ll bring excitement.

San Francisco 49ers (2-2) @ Arizona Cardinals (4-0)

Date: Sunday, October 10, 2021

Kickoff: 1:25 p.m. PT

Location: Glendale, Arizona

Network: Fox

Play-by-Play: Kevin Kugler

Color Analyst: Mark Sanchez

Sideline Reporter: Laura Okmin

Here’s a look at the TV map, courtesy of

If you are in the blue, you’ll get the 49ers/Cardinals game nationally. This is yet another reminder that the NFC East runs the NFL.

Live streaming: FuboTV (Try for free here!)

If you’re struggling to find a stream, then search on Twitter each team’s name or google them, and you’ll have plenty of options available.

Odds: Arizona -5, according to DraftKings Sportsbook.

Total: O/U 48

For more betting information, please visit DK Nation.

Odds/lines subject to change. T&Cs apply. See for details.