49ers vs. Colts: How to watch, stream, game time, and betting odds

The 49ers have their second home primetime game of the season as Jimmy Garoppolo will return as the starting quarterback to take on the Indianapolis Colts Sunday night. Indianapolis is without starting left tackle Braden Smith plus receivers, T.Y. Hilton, and Parris Campbell. However, the Colts did activate Quenton Nelson from the injured reserve.

Indianapolis Colts (2-4) @ San Francisco 49ers (2-3)

Date: Sunday, Oct. 24, 2021

Kickoff: 5:20 p.m. PT

Location: Santa Clara, California

Network: NBC

Play-by-Play: Al Michaels

Color Analyst: Chris Collinsworth

Sideline Reporter: Michelle Tafoya

No need for a TV map this week as the game will be on a national broadcast.

Live streaming: FuboTV (Try for free here!)

If you’re struggling to find a stream, then search on Twitter each team’s name or google them, and you’ll have plenty of options available.

Odds: 49ers -4, according to DraftKings Sportsbook.

Total: O/U 43

For more betting information, please visit DK Nation.

Vegas is predicting the 49ers to win 24-20.