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49ers vs Cardinals 2021 Game Day: Sunday, October 10, 2021; Game Time: 4:25 PM ET; TV: FOX; Stadium: State Farm Stadium

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The Arizona Cardinals (4-0) host the San Francisco 49ers (2-2) at State Farm Stadium on Sunday, October 10, 2021. 49ers vs Cardinals have met each other 59 times, with the Arizona Cardinals winning 27 games and the San Francisco 49ers winning 32 games. The Cardinals are surprisingly 4-0 and on top of the NFC West. A win over the 2-2 49ers would certainly help their cause in the division.