The NFL revealed its complete 272-game 2022 regular-season schedule on Thursday at 5:00 p.m. PT. NFL Kickoff Weekend will begin on Thursday, September 8, culminating with Super Bowl LVII on February 12, 2023, at State Farm Stadium in Glendale, Arizona. The San Francisco 49ers open their season on the road against the Chicago Bears. Their first home game comes during Week 2 against the Seattle Seahawks. The Niners' bye is during Week 9. They are currently scheduled to participate in five prime-time matchups this year. Watch 2022 NFR live each night on The Cowboy Channel+ from 10 pm ET. Here you will get What TV Channel is the NFR on Dish, DirecTV, and online streaming.