49ers vs Broncos: Game time, TV schedule, streaming and more

In the Niners' first prime-time game of the season, they’ll be facing a familiar foe in a new place that fans have been used to seeing twice a year in the past. While the Broncos under Russell Wilson’s leadership opened up as 2.5-point favorites, but the lines shifted quickly.

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Perhaps, the underwhelming performances by Denver in the first two weeks drove bettors to the 49ers, even though this was the starter-turned-backup-turned-starter Jimmy Garoppolo’s first week taking first-team reps in practice. Or, maybe, the dominating defensive showcase by San Francisco against the Seahawks swung the early money.

San Francisco 49ers (1-1) @ Denver Broncos (1-1)

Date: Sunday, September 25, 2022

Kickoff: 5:20 p.m. PT

Location: Denver, CO

Network: NBC

Play-by-Play: Mike Tirico

Color Analyst: Cris Collinsworth

Live streaming: FuboTV (Try for free here!)

Odds: 49ers -1.5 at DraftKings Sportsbook

Total: 44.5

For more betting information, please visit DK Nation.