Clelin Ferrell, who paid homage to Arik Armstead with a sack on the drive, had another tackle for loss to force 3rd & 13. Rushing from the inside, Nick Bosa destroyed the right guard and nearly came up with a sack. Dre Greenlaw was there to prevent Lock from scrambling, and Seattle had to force a punt.
Purdy would find Aiyuk on a scramble drill for a gain of 45 yards to begin the next possession. After a 12-yard run by McCaffrey, the Niners were inside of the red zone. On third down, Purdy threw the ball across his body over the middle. Samuel caught it, made a defender miss, before getting tackled at the one-yard line. Then, Samuel took a jet sweep to give the 49ers a 21-10 lead.
The defense would lose another starter as Dre Greenlaw appeared to take a helmet to the knee. Seattle would run a similar play that the 49ers ran and scored against them on last year on Thursday night football with George Kittle. It was a great design which pulled Seattle within four to make it 21-17.
Samuel wasn’t done, and his 30-yard catch and run on first down was the final play in an eventful third quarter. San Francisco averaged 10.7 yards per play through three quarters and had eight plays of at least 20 yards.
George Kittle would add to that number with a 44-yard touchdown reception. So make it nine plays of 20 yards or more and 11.4 yards per play.